Endocrine Disorders in Kidney Disease by Connie M. Rhee & Kamyar Kalantar-Zadeh & Gregory A. Brent

Author:Connie M. Rhee & Kamyar Kalantar-Zadeh & Gregory A. Brent
Language: eng
Format: epub
ISBN: 9783319977652
Publisher: Springer International Publishing

Statin Therapy and Adverse Outcomes/Safety in CKD

The safety of statins has been a subject of debate from the appearance of this class of therapeutic agents. Early assessment of the reports of adverse events has resulted in an opinion that statin therapy should be used with caution in CKD patients. This opinion was based mostly on the theoretical consideration that metabolite accumulation and uremia-related muscle injury could increase the risk of myopathy [56]. To date, there is no epidemiological confirmation of this opinion or that statin-treated patients across any CKD stage including dialysis had a higher risk of adverse events [22]. Moreover in studies using high-dose atorvastatin [57] or high-dose rosuvastatin [58] in NDD-CKD patients, the risk of adverse events was no higher than in patients with normal renal function.

More recently a large number of studies have addressed the association between statin therapy and incident diabetes as well as acute kidney injury (AKI).

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